Barcelona, Spain
A research conducted by scientists at the Salk Institute in California led by Spanish Juan Carlos Izpisúa found the key to repairing damaged hearts, so far only in mice.
The scientists, who published their work in the journal Stem Cell Cell , are as collecting heal the hearts of rodents by blocking four molecules that are capable of inhibiting programs for organ regeneration, which opens the door to new treatments for heart disease.
The Hospital Clinic of Barcelona, who participated in this international project through Dr. Josep M. Campistol, the transfer of these results arises in patients with severe and irreversible disease.
The research suggests that, although as a rule adult mammals are unable to regenerate damaged tissues, they may retain a latent ability that is present during embryonic development.
The Izpisúa group, which collaborates Campistol, time consuming trying to find the elements that control and trigger the regeneration in organisms that are capable of carrying it out
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“We know that these types of studies require time and many stages, but these results place us in an unprecedented scenario. Further work, “they say.
Laboratory Izpisúa pioneered identify many essential molecules that define vertebrate development.
In 2003, the group identified the signals responsible for heart regeneration in zebrafish and in 2010 described in a paper published in the journal Nature how the process was conducted.
This study revealed that cardiac cells have the capacity to become more immature, similar to the precursor cells of the heart cells, allowing them to multiply and regenerate damaged tissue.
“For this work we have focused on the results obtained with zebrafish and have thought that if they know how to regenerate tissue, there must be something we can teach,” said Aitor Aguirre, another project scientists.
The next step scientists raised now is to move to other animals and check regenerative reprogramming can work on them.
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