Reuters, 15/01 19:29 CET
The first author of this study is Stefanie Wurm and work is led by Erwin Wagner, head of the BBVA Foundation-CNIO Cancer Cell Biology Program. EFE / File
Madrid, Jan 15 ( EFE ) .- A team from the National Cancer Research Centre ( CNIO ) has found a new key molecular mechanism for the formation of the skin.
In the formation of human skin involves a cascade of yet well known biochemical signals, but very important because its judgments cause diseases that affect more than a quarter of humanity-from atopic dermatitis skin-cancers, today reported the CNIO in a press release.
The work of this center now contributes to unveil the process discovering “one of the key links”, a new mechanism that regulates -evolución- differentiation of cells that make up most of the epidermis, keratinocytes.
In addition, it was found that this mechanism could be involved in skin cancer.
In particular, researchers have identified Fra-2 protein whose precise function in the skin was unknown so far as the key element in keratinocyte differentiation. if Fra-2 is not activated and no differentiation skin thus formed does not finish
Human keratinocytes live about a month and in that period go through a series of related to the different functions performed during its journey from the deepest layer of the epidermis, where they are born until the surface with which the body touches the exterior changes.
In technical terms, this evolution of keratinocytes is called differentiation.
“In the epidermis, the induction of keratinocyte differentiation is essential for the acquisition of the barrier function of the skin, and to homeostasis (stability) of tissue “, the authors of this article published in the journal” Genes & amp; Development “.
The first author of this study is Stefanie Wurm and work is led by Erwin Wagner, head of the Foundation BBVA-CNIO Cell Biology Cancer.
euronews published from Reuters as, but not involved in the published articles.
Copyright 2015 EFE.
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